MICU藥品配製1080215 | 桂圓生存手冊

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MICU藥品配製 2018/02/15 李依玟藥師整理

	配製法	濃度	單位	給藥	Dose	60kg/hr	70kg/hr	80kg/hr
Amiodarone 150mg/3mL/Amp	6# in D5W 500 ml	1.74	mg/ml		*前6 hrs: 34 cc/hr, 後18hrs: 17 cc/hr	ㅤ	ㅤ	ㅤ
Atracurium 25mg/2.5mL/Amp	Pure	10	mg/ml	CVP	Initial bolus of 0.4 to 0.5 mg/kg, → 0.24 to 1.2 mg/kg/hour	2.4-3 ml	2.8-3.5 ml	3.2-4 ml
ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	1.4-7.2 ml	1.6-8.4 ml	1.9-9.6 ml
Cisatracurium 10 mg/5 ml/Amp	Pure	2	mg/ml	CVP	Initial bolus of 0.1 to 0.2 mg/kg → 0.06 to 0.18 mg/kg/hour	3-6 ml	3.5-7 ml	4-8 ml
ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	2-6 ml	2.1-6.3 ml	2.4-7.2 ml
Dexmedetomidine 200mcg/2mL/Vial	1# + NS 48 ml	4	mcg/ml		Initial 0.5 to 1 mcg/kg → 0.2 to 0.7 mcg/kg/hour [4]	7.5-15 ml 3-10 ml	8.75-17.5 ml 3.5-12.25 ml	10-20 ml 4-14 ml
Dobutamine 250 mg/20 ml/Vial	2# in NS 250 ml	2000	mcg/ml	CVP	120-1200 mcg/kg/hour	3.6-36 ml	4.2-42 ml	4.8-48 ml
ㅤ	4# in NS 250 ml	4000	ㅤ	ㅤ	ㅤ	1.8-18ml	2.1-21 ml	2.4-24 ml
Dopamine 200mg/5ml/Amp	2# in NS 250 ml	1600	mcg/ml	CVP	HR: 300 to 600 mcg/kg/hr BP: >600 mcg/kg/hr	11.25-22.5 ml >22.5 ml	13-26 ml > 26 ml	15-30 ml > 30 ml
ㅤ	4# in NS 250 ml	3200	ㅤ	ㅤ	HR: 300 to 600 mcg/kg/hr BP: >600 mcg/kg/hr	6 -11 ml >11 ml	6.5-13 ml > 13 ml	7.5 - 15 ml > 15 ml
Epinephrine 1 mg/ml/Amp	10# in NS 250 ml	40	mcg/ml	CVP	6-30 mcg/kg/hr	9 – 45 ml	10.5-52 ml	12-60 ml
Fentanyl 0.05 mg/mL 10mL/Amp Fentanyl 0.1 mg/2 ml/Amp	Pure	50	mcg/mL		0.7 to 10 mcg/kg/hour [4]	1 - 12 ml	1-14 ml	1-16 ml
Isoproterenol 0.2mg/mL/Amp	10# in NS 250 ml	8	mcg/mL	CVP	Cardiogenic shock due to bradycardia: 120-1200 mcg/hr	15-150 ml	ㅤ	ㅤ
Labetalol 25mg/5mL/Amp	10# in NS 250 ml	1	mg/ml		Initial: 30 to 120 mg/hr	30-120 ml	ㅤ	ㅤ
Lidocaine 2% 100mg/5mL/Amp	10# in NS 250 ml	4	mg/ml				ㅤ	ㅤ
Lorazepam 2 mg/ml/Amp	1# + NS 1 ml	1	mg/ml		0.01 -0.1 mg/kg/hour (Max: 10ml/hr)[4]	0.6-6 ml	0.7-7 ml	0.8-8 ml
ㅤ	10# in NS 250 ml	0.08	ㅤ	ㅤ	ㅤ	7.5-75 ml	8.75-87 ml	10-100 ml
Midazolam 15 mg/3ml/Amp	Pure	5	mg/ml	CVP	Sedation: 0.02 to 0.1 mg/kg/hour [4] Status epilepticus:0.05 to 2 mg/kg/hr[5]	0.24 -1.2 ml 0.6 – 24 ml	0.28-1.4 ml 0.7 – 28 ml	0.32-1.6 ml 0.8 - 32 ml
ㅤ	10# in NS 250 ml	0.54	ㅤ		ㅤ	2.4 -12 ml 6 - 240 ml	2.8-14 ml 7 - 280 ml	3.2-16 ml 8 - 32 ml

	配製法	濃度	單位	給藥	Dose	60kg/hr	70kg/hr	80kg/hr
Morphine 10 mg/ml/Amp	10# in NS 250 ml	0.4	mg/ml		Analgesia for MV: 0.07-0.5 mg/kg/hr[4]	10.5-75 ml	12.25-87.5 ml	14-100 ml
ㅤ	10# in NS 100 ml	1	ㅤ	ㅤ	ㅤ	4.2 -30 ml	4.9-35 ml	5.6-40 ml
Nicardipine 10mg/10mL/Amp	1# in 100 ml	0.1	mg/ml	CVP	Initial: 3-5 mg/hour (Max: 15 mg/hr) pure易造成靜脈炎(小心)	30-50 ml	ㅤ	ㅤ
ㅤ	Pure	1	ㅤ	ㅤ	ㅤ	3-5 ml	ㅤ	ㅤ
Norepinephrine 4mg/4mL/Vial	8# in D5W 500 ml 4# in D5W 250 ml 2# in D5W 125 ml	60.15	mcg/ml	CVP	Initial: 480-720 mcg/hr [1](Max: 1.8 mg/hr)[3] Range: 1.8 -180 mcg/kg/hr [2]	8-12 ml ( Max: 30 ml)	ㅤ	ㅤ
ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	1.8-180 ml	2.1-210 ml	2.4-240 ml
Propofol 200mg/20mL/Amp	Pure	10	mg/ml	CVP	Sedation: Initial: 0.3 mg/kg/hour → 0.3 to 3 mg/kg/hour[4] Status epilepticus: 1.8 to 12 mg/kg/hour[5]	1.8 ml	2.1 ml	2.4 ml
ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	1.8-18 ml	2.1-21 ml	2.1-24 ml
ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	10.8-72 ml	12.6-84 ml	14.4-96 ml
Rocuronium 50mg/5mL/Vial	Pure	10	mg/ml	CVP	Initial bolus of 0.6 to 1 mg/kg → 0.48 to 0.72 mg/kg/hour	3.6-6 ml	4.2-7 ml	4.8-8 ml
ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	ㅤ	2.88-4.32 ml	3.36-5 ml	3.8-5.76ml
Vasopressin 20 U/ml/Amp	5# in NS 250 ml	0.4	unit/ml	CVP	1.2-2.4 Unit/hr	3-6 ml/hr	ㅤ	ㅤ

Reference:

Manufacturer: Product Information

Steven M. Hollenberg, MD: Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit. Care Med 2004 Vol. 32, No. 9

Nina Vadiei: Impact of Norepinephrine Weight-Based Dosing Compared With Non–Weight-Based Dosing in Achieving Time to Goal Mean Arterial Pressure in Obese Patients With Septic Shock. Annals of Pharmacotherapy 2016

Juliana Barr, MD: Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit. Crit. Care Med 2013.

Gretchen M. Brophy: Guidelines for the Evaluation and Management of Status Epilepticus. Neurocritical Care Society 2012